Cutting Edge Technologies for

Cell- and Molecular Biosciences in the Nordics

Creating value for our customers, suppliers and staff, and ultimately for the public who benefits from scientific discovery. 

What we operate in

Cell Biology

Faster and Easier Flow Cytometry Sample Prep, Synthetic mRNA for Research and Clinical Labs, Next Generation Cell Recovery for Immuno-Oncology etc.

Diagnostics

Anti-Müllerian Hormone (AMH) Quality Control, RIQAS Anti-SARS-CoV-2 Serology EQA Programme, Molecular Controls for Infectious Disease etc.

Genomics

Tapestri Solution for Tumor Profiling in Single Cell, Ultimate Exonic Coverage, Liquid Biopsy Panels etc.

NGS, PCR, qPCR

Direct PCR of Crude Samples without Template Purification, highQu PCR & qPCR Reagents Performance Excellence etc.

Proteomics

Electrospray ionization emitters, RAS proteins for oncology research, MagReSyn NTA beads etc.

Water purification and filtering

Genie Purist: Dedicated for Ultrapure (Type I) Water, Operational Reliability and Ease-of-Use etc.

News & Highlights

ThinkCyte logo

Label-Free Cell Characterization and Sorting Empowered by AI

Based on the core technology Ghost Cytometry which enables supervised or unsupervised machine learning-based sorting, ThinkCyte offers the platform VisionSort. 

The system provides cellular fingerprints with morphometric readouts in high resolution, on top of standard fluorescence-based sorting.

VisionSort is the perfect addition to conventional cell sorters, by providing unbiased, label-free cell characterization and sorting, supported by an embedded AI algorithm.

Biolegio logotype oligonucleotide synthesis

Custom oligonucleotide synthesis; high quality service, speed and flexibility

Biolegio offers a range of products, spanning from highly modified and specialised oligos, to standard DNA oligo synthesis.

Applications covered are sequencing, NGS, PCR, Realtime-PCR, SNP detection, genotyping, gene expression and mutation detection.

  • Long oligo synthesis
  • Modified and standard oligos
  • Probes for Realtime-PCR
  • Custom RNA synthesis
  • NGS grade oligonucleotides
  • Bulk scale synthesis 7 OEM oligos
  • SARS-CoV-2 primers & probes
 
MissionBio single cell MRD vision image

Mission Bio Announces Launch of Single-Cell Measurable Residual Disease (MRD) Assay Aimed to Advance Personalized Healthcare for Blood Cancer Patients

As the only solution to integrate genotypic and immunophenotypic assessment, the scMRD AML Multiomics Assay targets 40 genes for single-cell DNA sequencing based on current international AML MRD guidelines, such as European LeukemiaNet, and 17-plex antibody-oligonucleotide conjugate (AOC) panel curated for key biomarkers associated with AML MRD. 

Through a seamlessly integrated workflow, the assay allows clinician-researchers to:

  • Distinguish true MRD from pre-leukemic or precursor clones with a limit of detection of 0.01%,
  • Reveal clonal architecture (co-occurrence and zygosity of mutation) and uncover the order of acquisition of mutations (phylogeny),
  • Track clonal dynamics and immunophenotypic drifts through disease course to identify therapeutic targets and therapy-resistance subclones.
Cell suspension sample prep

Enabling Accurate Biological Analysis Through Automation

Laminar Wash technology makes it easy for applications that require a high degree of automation such as screening final product for cell therapeutics. Laminar Wash systems can replace centrifuge integrations and only require one robotic movement instead of over 20 movements. Integration using Laminar Wash technology can:

  • Reduce hands-on time and save FTE resources
  • Lower the CVs of results
  • Easily accomodate on-deck or off-deck automation

Special Offer: Hot Start PCR with Less Side Products, ALLin™ Hot Start Taq Polymerase & Mastermix

Superior sensitivity polymerase generating less side products and low copy detection in complex
templates with size up to 6 kb. Highly specific polymerase thanks to efficient blocking at room
temperature. The ALLin™ Buffer includes dNTPs, Magnesium, enhancers, and stabilizers.

10% 2nd Quarter Discount

Celemics WES sequencing

Celemics Whole Exome Sequencing Panel

Celemics Whole Exome Sequencing Panel is the most comprehensive WES panel in the market, covering all target regions of major WES panels in the market.

The panel does not compromise uniformity and performs well against hard-to-capture regions such as GC-rich regions.

Azure chemiSOLO chemiluminescence imager

New Azure chemiSOLO personal chemiluminescent imager

The chemiSOLO detects low-expressing proteins with femtogram sensitivity and captures marker images at the push of a button.

A unique web browser interface allows the chemiSOLO to be controlled by phone, tablet, or PC, without the need to install any additional software.

In addition to Western blots, the chemiSOLO captures pictures of colorimetric blots or visible stained protein gels, like Coomassie blue or silver stain.

The chemiSOLO’s wide dynamic range can be further enhanced by using EDR, our Extended Dynamic Range function. This feature allows for linear, quantitative data, while avoiding saturation.

Celloger Nano Real-Time Cell Monitoring

The super compact and intuitive live cell imaging system, Celloger Nano- got everything you need to perform your sophisticate laboratory works. Equipped with exceptional flourescence and auto focusing technology, precise stage controller, and user-friendly software, accelerates your cell-based research works.

Acusera serum indices quality control

Identiy pre-analytical errors in haemolyzed, icteric and lipemic (HIL) samples

The Randox Acusera Serum Indices control is designed to be used to monitor an IVD instrument’s response in the detection of haemolyzed, icteric and lipemic (HIL) samples. This control can be utilised in laboratory interference testing to assist in improving error detection of pre-analytical errors affecting clinical chemistry testing.

This control provides a full range of clinically relevant testing levels, including a negative (-) and three positives (+, ++ & +++)

Lipid Nanoparticles

Non-viral gene delivery with lipid nanoparticles

OZ Biosciences can support every stage of your mRNA-LNP production, from mRNA
synthesis to LNP formulation development, manufacturing and fill & finish.
For any of RNA, DNA or APIs encapsulation, you can provide us with your molecule of
interest and we will formulate it into LNP´s.

  • Custom LNP design services
  • Most advanced nucleic acid delivery system for gene therapy
  • Custom mRNA synthesis services
Digestif

Two-in-one quality control for tryptic digestion and LC-MS performance

Digestif is a universal protein standard to simultaneously assess the quality of sample workup and the performance of your LC-MS system.

  • Control and optimise digestion efficiency
  • Monitor retention times in LC-MS

 

Events

EMERGE Episode 19 with Sudip Gosh “Deep proteomic insight into disease biology identifies age-specific vulnerabilities in acute leukemia”

Wednesday May 29 2024, 4:00 pm (CET)

Infant and adult MLL1/KMT2A-rearranged (MLLr) leukemia represents a disease with a dismal prognosis. Here, we characterized early proteomic events of MLL::ENL-mediated transformation in fetal and adult blood progenitors and reveal that whereas adult pre-leukemic cells are mainly characterized by retained myeloid features and downregulation of ribosomal and metabolic proteins, expression of MLL::ENL in fetal lymphomyeloid multipotent progenitors (LMPPs) leads to enrichment of translation-associated and histone deacetylases signaling proteins, and decreased expression of inflammation and myeloid differentiation proteins. Integrating the proteome of pre-leukemic cells with their secretome and the proteomic composition of the extracellular environment of normal progenitors highlights ligand-receptor interactions with differential regulation upon initiation of fetal- and adult-origin leukemia. We show that these interactions have implications for human MLLr leukemia cells’ ability to communicate with their environment through granule proteins. Our study has uncovered opportunities for targeting ontogeny-specific proteomic vulnerabilities in in utero-initiated and adult-onset MLLr leukemia.

EMERGE Episode 18 with Patricia Bortel and “Systematic optimization of automated phosphopeptide enrichment for high-sensitivity phosphoproteomics”

Wednesday April 24 2024, 4:00 pm (CET)

Improving coverage, robustness and sensitivity is crucial for routine phosphoproteomics analysis by single-shot liquid chromatography tandem mass spectrometry (LC-MS/MS) from minimal peptide inputs. The presentation focuses on our systematic optimization of key experimental parameters for automated on-beads phosphoproteomics sample preparation with focus on low input samples, pinpointing critical variables influencing the resulting phosphoproteome. Furthermore, we evaluated how sequential enrichment can boost phosphoproteome coverage and show that pooling fractions into a single LC-MS/MS analysis can increase the depth. The presentation also includes an alternative phosphopeptide enrichment strategy based on stepwise addition of beads thereby boosting phosphoproteome coverage. Our optimized phosphoproteomics pipeline can be translated to the newest generation of mass spectrometers, such as the Orbitrap Astral, increasing the phosphopeptide coverage by 2-fold, allowing for deep phosphoproteomics analysis without the need to scale up the starting cell amounts.

Streamlined proteome-wide identification of drug targets indicates organ-specific engagement

Wednesday April 3 2024, 4:00 pm (CET)

Proteins are the primary targets of almost all small molecule drugs. Nonetheless, even drugs designed with high specificity may interact with multiple proteins that are not initially targeted. Discovering these potential interactions is crucial for the development and repurposing of drugs. Current state-of-the-art proteomics methodologies enable screening of thousands of proteins against a limited number of drug molecules. Here we report the development of a label-free quantitative proteomics approach that enables proteome-wide screening of small organic molecules in a scalable, reproducible, and rapid manner by streamlining the proteome integral solubility alteration (PISA) assay.

STREAMLINED PROTEOME-WIDE IDENTIFICATION OF DRUG TARGETS INDICATES ORGAN-SPECIFIC ENGAGEMENT | bioRxiv

Immunopeptidomics: Isolation of sHLA Peptides from Plasma

Wednesday Nov 8 2023 5 pm (CET)

Soluble HLA (sHLA) peptides are thought to have great potential as biomarkers for different diseases such as cancer. However, efficient enrichment of sHLA peptides from body fluids like plasma has been a bottleneck, requiring 3-5 ml per patient. Here we present IMBAS-MS, an automated magnetic bead based workflow for the efficient enrichment of HLA protein peptide complexes.

The core of IMBAS-MS is the combination of biotinylated antibodies captured by streptavidin magnetic beads allowing for an automated one pot enrichment from only 200 µl plasma.

In combination with Whisper low-flow gradients, data-independent acquisition (DIA) and computational library-based analysis we acquire deep immunopeptidomes from single measurements, elucidating its origins.

Mission statement: Life science, inspired

The importance of customers´ needs

We understand our customers’ needs and know how to operate flexibly in a quickly changing but always demanding market.

10 000 +

Products

Instruments and reagents based on innovation for improved laboratory methods.

1 000 +

Satisfied Customers

Networking with 1000´s of individual scientists in Denmark, Finland, Norway, Sweden, Iceland and Baltic countries.

20 +

Years Of Experience

We know how to operate flexibly in a quickly changing but always demanding market.

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